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Dr. Charles D. Eggleton

Professor, ChairEggleton_Primary

Department of Mechanical Engineering
University of Maryland, Baltimore County
1000 Hilltop Circle Baltimore, MD 21250

Phone: (410) 455-3334
Office: ENGR205


Ph.D., Aeronautics and Astronautics, Stanford, 1994
M.S., Aeronautics and Astronautics, Stanford, 1989
B.S., Naval Architecture, University of California, 1986

Employment History

2012 – present Chair, Mechanical Engineering Department, UMBC
2012 – present Professor, Mechanical Engineering, UMBC
2004-2012 Associate Professor, Mechanical Engineering, UMBC
1998-2004 Assistant Professor, Mechanical Engineering, UMBC

Honors and Awards

NIH R01 Computational Model of Cellular Adhesion in Bulk Flows, Principal Investigator
NSF S-STEM Diversification and Retention: Creating New Paths of Success for STEM Scholars in Mechanical Engineering, Co-Investigator
1987 – 1990  NSF Graduate Minority Fellowship

Research Interest

My research program is focused on solving problems that involve deformable particles including biological cells, their mechanical behavior, and the influence of hydrodynamic forces and applied external forces on their behavior.  We are especially interested in understanding how mechanics on the cellular scale, micron and nano, determine physiological response. Funded in recent years by the NIH, our studies focus on the effect of cell compliance on adhesion –detachment to substrates and other cells using theoretical and numerical models. These models are used to determine the kinetic properties of single intermolecular bonds at the nanoscale by analyzing data obtained from experiments and design strategies to enhance leukocyte adhesion or disrupt bacterial adhesion in order to prevent infections.

I am also interested in developing high throughput measurements of cell mechanical properties. Recently, we have include optical forces in our modeling efforts that allow us to simulate the response of cell in microfluidic devices  that is being used in the design of optical-based separators for isolation and manipulation of individual cells for bioanalysis.

Classes Taught at UMBC

ENME 320
ENME 640
ENME 645
Fluid Mechanics
Fluids/Energy Laboratory
Fundamentals of Fluid Mechanics I
Applied Computational Thermo/Fluids

Selected Publications

You can find my publications on Google scholar by clicking here.

Balsara, H.D., Banton R.J.., & Eggleton, C. D. (2016). Investigating the effects of membrane deformability on artificial capsule adhesion to the functionalized surface. Biomechanics and Modeling in Mechanobiology, 15(5), 1055-1068

Roth, K.B., Eggleton, C.D., Neeves, K.B. & Marr D. W. M. (2013) Measuring cell mechanics by optical alignment compression cytometry. Lab on a Chip 13 (8), 1571-1577

Gupta, V.K., Neeves, K. B., & Eggleton, C.D.  (2012). Effect of viscoelasticity on the analysis of single-molecule force spectroscopy on live cells. Biophysical Journal 103 (1), 137-145

Sraj, I., Szatmary, A.C., Desai, S. A., Marr, D. W. M. & Eggleton, C.D. (2012). Erythrocyte deformation in high-throughput optical stretchers. Physical Review E 85 (4), 041923

Gupta, V.K., Sraj, I. A., Konstantopoulos, K., & Eggleton, C.D.  (2010). Multi-scale simulation of L-selectin–PSGL-1-dependent homotypic leukocyte binding and rupture. Biomechanics and Modeling in Mechanobiology, 9 (5), 613-627

Gonzalez-Mancera, A., Gupta, V.K., Jamal, M., & Eggleton, C.D. (2009). Effects of a surfactant monolayer on the measurement of equilibrium interfacial tension of a drop in extensional flow. Journal of Colloid And Interface Science 333, 570-578.

Jadhav, S., Eggleton, C. D., & Konstantopoulos, K. (2005). A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling, Biophyical Journal, 88, 96-104.

Davidson, K. M., Shrinivasan, S., Eggleton, C. D., & Martin, M. R. (2003). Using computational fluid dynamics to estimate circulation time distributions in Bioreactors. Biotechnology Progress, 19, 1480-1486.

Eggleton, C.D., Tsai, T.M., & Stebe, K.J., (2001). Tip streaming from a drop in an extensional flow in the presence of surfactants. Physical Review Letters, 87(4).